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ERIC Number: EJ1120586
Record Type: Journal
Publication Date: 2016-Dec
Pages: 9
Abstractor: As Provided
ISSN: ISSN-1072-0502
Computational Model of a Positive BDNF Feedback Loop in Hippocampal Neurons Following Inhibitory Avoidance Training
Zhang, Yili; Smolen, Paul; Alberini, Cristina M.; Baxter, Douglas A.; Byrne, John H.
Learning & Memory, v23 n12 p714-722 Dec 2016
Inhibitory avoidance (IA) training in rodents initiates a molecular cascade within hippocampal neurons. This cascade contributes to the transition of short- to long-term memory (i.e., consolidation). Here, a differential equation-based model was developed to describe a positive feedback loop within this molecular cascade. The feedback loop begins with an IA-induced release of brain-derived neurotrophic factor (BDNF), which in turn leads to rapid phosphorylation of the cAMP response element-binding protein (pCREB), and a subsequent increase in the level of the ß isoform of the CCAAT/enhancer binding protein (C/EBPß). Increased levels of C/EBPß lead to increased "bdnf" expression. Simulations predicted that an empirically observed delay in the BDNF-pCREB-C/EBPß feedback loop has a profound effect on the dynamics of consolidation. The model also predicted that at least two independent self-sustaining signaling pathways downstream from the BDNF-pCREB-C/EBPß feedback loop contribute to consolidation. Currently, the nature of these downstream pathways is unknown.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A