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ERIC Number: EJ1120536
Record Type: Journal
Publication Date: 2016-Dec
Pages: 4
Abstractor: As Provided
ISSN: ISSN-1072-0502
Repeated Recall and PKM? Maintain Fear Memories in Juvenile Rats
Oliver, Chicora F.; Kabitzke, Patricia; Serrano, Peter; Egan, Laura J.; Barr, Gordon A.; Shair, Harry N.; Wiedenmayer, Christoph
Learning & Memory, v23 n12 p710-713 Dec 2016
We examined the neural substrates of fear memory formation and maintenance when repeated recall was used to prevent forgetting in young animals. In contrast to adult rats, juveniles failed to show contextual fear responses at 4 d post-fear conditioning. Reconsolidation sessions 3 and 6 d after conditioning restored contextual fear responses in juveniles 7 d after initial training. In juveniles that received reconsolidation sessions, protein kinase M zeta (PKM?) increased in the amygdala, but not in the hippocampus. These data suggest that repeated reminders and increased PKM? maintain fear responses in juvenile animals that otherwise would not exhibit this behavior.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A