This paper reports on the initial stages of an empirical study of a new secondary school in New Zealand. The school vision and organisation reflect current international twenty-first-century learning discourse by confronting long-established beliefs concerning the nature of education and knowledge and the roles of teachers and students. The school's focus is on developing the dispositions and competencies of students through thematic, intersubject, inquiry-based learning. While these twenty-first-century ideas appear widely accepted worldwide, there is little research on the impact of these ideas on student learning. This study considers the challenges faced by the school in moving from aspirational vision to curriculum enactment during its first 18 months of operation. The focus of this paper is the curriculum design and development process. The issues faced by staff in this twenty-first-century school will be of interest to educationalists worldwide who are involved with the planning of new schools and curricular innovation within existing schools. Four key questions that arise from the study and that will form the focus of future research are identified.