With the development of digital technologies, various disruptive innovations have emerged that are gradually replacing academic libraries in the information-seeking process. As academic libraries become less relevant to their users, it is imperative that they develop strategies to respond to disruption. We highlight the fact that the service mission of academic libraries is in alignment with service innovation and propose that academic libraries respond to disruption by accelerating service innovation. Applying the Resources-Processes-Values framework, we recommend that, to facilitate service innovation, high-level administrators become innovation leaders, foster an innovation-supportive culture, tie performance evaluations and rewards to innovation outcomes, and create dedicated innovation teams with high levels of decision-making autonomy. We also recommend that academic libraries involve their users and build partnerships with other libraries and with commercial communities to bring about service innovation necessary to respond to disruption.