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ERIC Number: EJ1119045
Record Type: Journal
Publication Date: 2016
Pages: 9
Abstractor: As Provided
ISSN: EISSN-1306-3065
Free Radical Pathology of the Body in the Long-Term Period under Combined Exposure to Gamma Radiation and Emotional Stress in the Experiment
Ilderbayeva, Gulzhan O.; Suleymeneva, Dametken M.; Ilderbayev, ?ralbek Z.; Argynbekova, Ainur S.; Berekenova, Gulnar A.; Syzdykaeva, Sayrangul M.; Kabdykanov, Symbat K.
International Journal of Environmental and Science Education, v11 n17 p9873-9881 2016
We have studied the intensity of free radical and antioxidant processes in organs (liver, spleen, thymus, lymph nodes of the small intestine, and adrenal glands) and cells (lymphocytes) in the long-term period after combined exposure to a sublethal dose of ?-radiation (6 Gy) and emotional stress. Combined exposure was followed by accumulation of LPO CD and MDA (conjugated dienes and malonic dialdehyde) products in homogenates of the studied organs. To achieve the goal set, experiments were conducted on 40 outbred white mature male rats randomized into groups. The results of the study indicate major changes in lipid peroxidation and antioxidant system under emotional and radiation stress. Ionizing radiation has a dominating role under combined emotional and radiation aftereffect. This resulted in inhibition of antioxidant protection enzymes and development of dual-oxidative stress in experimental animals. Impaired functional relationships of catalytic redox system of glutathione accompanied by inhibiting orientation of changes in activity of glutathione-dependent enzymes, and prolonged tension of the links of antioxidant system can eventually lead to a decrease in antioxidant status of the body, which indicates the need for the development of advanced methods for adaptive correction.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A