The study investigated the attitudes of secondary school students towards science in Odeda Local Government Area of Ogun State, Nigeria. Two hundred senior secondary school students consisting of 84 males and 116 females were selected from five secondary schools using stratified random sampling techniques. A 20-item Attitude to Science Questionnaire on a five-point Likert scale was adopted for the study. The instrument has a reliability coefficient of 0.73 using Cronbach's reliability method. Frequency counts and percentages were used to obtain an overall picture of students' attitude towards science while student's t-test was used to find out whether there was significance difference between the attitude of male and female students. Findings showed that a higher proportion of the students display positive attitude towards science. Also, there was no significant difference between the attitude of male and female students towards science.