Over the years, mnemonic instruction has been promoted as an effective strategy to teach students with learning problems including learning disabilities (LD) or mild intellectual disability (MID). This paper discusses mnemonic instruction, including types, versatility in use, and effectiveness with struggling learners. Specific emphasis then is placed on research on mnemonic strategies in the content areas of science and social studies. The paper concludes with a discussion of how mnemonic strategies can be effectively used with students with learning problems to enhance performance.