The use of technology in classrooms has been considered as the solution to social, economic and educational problems since its introduction to education in mid-1970. There have been many studies conducted on the different aspects of the use of technology in teaching and learning. However, study on teaching with Blended Learning in teaching and learning has not been highlighted especially in Malaysian context. It examines the effects of the exogenous variables towards with use of Blended Learning in teaching and learning among secondary teachers. The proposed research variables are based on previous models of technology acceptance. A total of 98 secondary teachers completed the questionnaire measuring their responses to computer attitudes (CA), computer teaching efficacy (CTE) and school environment (SE) and Blended Learning (BL). Structural Equation Modelling (SEM) was used as the main technique for data analysis. All hypotheses were supported by the data and have direct effects towards Blended Learning use. To sum up, the study provided larger implications for development in theory, practices and policymaking that could be related to the BL use among teachers.