The relevance of the research problem is inspired by the need to ensure decent work principles in Russia. The purpose of this article is to develop evaluation methodologies and identify areas to implement key principles of decent work at the regional level in modern Russia. A leading approach to study this problem is the development of a new method of calculating the index characterizing the decent work deficit in the region. Results: the authors have developed a general procedure for overcoming the decent work deficit, given the chosen model of development in the regions, and developed the stages of events. In the study, the authors analyzed the existing approaches to the assessment of decent work, taking into account the updated development trends of the economy, its key parameters. There are presented results of a comparative analysis on decent work deficits at the regional level, identified the problem field of assessment methodology and proposed measures to ensure patterns of decent work with regard to the choice of innovative development in regional economies. The advantage of this model is overcoming the decent work deficit through structural, institutional changes, increasing investment activity. The article may be useful for research organizations and regional administrative structures in the development of medium and long-term programs to increase decent work levels.