Background: Studies have revealed that overweight adults with type 2 diabetes have low rates of physical activity and are resistant to change. Purpose: The purpose of this study was to use construct validation of intervention methods to examine the impact of a 4-week behavioral intervention on the use of self-regulation skills for physical activity among overweight and obese adults with type 2 diabetes mellitus (T2DM). Methods: This study used a randomized control group design with pre- and posttesting. A 4-session theory-based intervention focused on applied, experienced-based assignments to encourage the use of self-regulation strategies. Results: The intervention produced statistically significant increases in the use of the following self-regulation skills: self-monitoring, goal setting, self-reward, social support, time management, and overcoming barriers. Translation to Health Education Practice: Health Educators can employ experience-based intervention to increase the use of self-regulation skills to support physical activity adherence.