This paper is a study of blended learning pedagogy in open and distance learning (ODL), involving two universities in Southeast Asia, STOU Thailand and UT Indonesia. The purpose of this study is to understand the issues related to the implementation of blended-learning pedagogy. Qualitative case study was employed to optimize my understanding of the blended learning phenomena gathered through semi-structured interview and documentary analysis. Whilst they operated in different educational settings, these two universities shared similarities. They have developed blended learning pedagogy to promote students' learning classified into three dimensions: printed learning materials, F2F sessions, and online learning. Printed materials, however, may be identified as a major one and online learning have been regarded as strategic policies for further development. They have been equipped with their VLE; the use of VLE helped these universities to provide two-way traffic communications. This study identifies some strategic best practices in developing blended learning pedagogies in ODL universities in Southeast Asia. This study also provides practical recommendation that internet-based instruction is now becoming a strategic choice for ODL in developing countries to widening access and to meet challenges for better future.