Undocumented Latina/o college students face obstacles and stressors; their stressful experiences and academic strengths merit empirical attention. This cross-sectional, mixed-methods study explored stress, depression, grit, and grade point average (GPA) of 84 non-citizen, Latina/o first-generation college students with a comparison group of 180 citizen, Latina/o first-generation college students in Maryland. Qualitative interviews were conducted with 21 non-citizens and 26 citizens, after conducting a quantitative online survey. Immigrant status moderated the relation between depression and GPA in addition to grit and depression. Qualitative findings suggested that stress for citizens and non-citizens centered on financing college, but non-citizens faced additional stress due to policies pertaining to immigration status. Both groups displayed grit in navigating obstacles and contained their emotions with positive self-talk, but most non-citizens did not turn to anyone outside of the family for support. Findings hold implications for ecological processes and achievement among Latina/o undocumented college students.