In this study, the authors examined the moderating effects of partnership on the relationship between services and supports adequacy and family quality of life (FQOL) for families of children with deaf-blindness ages birth to 21. A social-ecological approach enabled examining the impact of disability on the family system. A survey, consisting of four measures, was completed by 227 parents of children with deaf-blindness. Results suggest that FQOL for families of children with deaf-blindness is explained, in part, by satisfaction with the adequacy of friend and family supports and child-care services. Satisfaction with partnership also significantly predicted FQOL for these families. Significant interaction effects indicated that the relationships (a) between education services adequacy and FQOL and (b) between related services adequacy and FQOL are dependent on satisfaction with partnership. Implications for research and practice are discussed.