An attempt has been made to assess and identify the major variables that influence student academic achievement at college of natural and computational science of Wolaita Sodo University in Ethiopia. Study time, peer influence, securing first choice of department, arranging study time outside class, amount of money received from family, good life later on and father's education level are major variables which influence the academic achievement of students at college of natural and computational science of Wolaita Sodo University, Ethiopia using binary logistic regression model.