The purpose of this research is to develop and implement an economic and geographic approach to forming and developing geographic (territorial) industrial clusters in regions of Kazakhstan. The purpose necessitates the accomplishment of the following scientific objectives: to investigate scientific approaches and experience of territorial economic development; to investigate the developmental trends and territorial concentration of the economy in the West Kazakhstan region; to determine the prospects of formation and recommendations regarding the development of geographic (territorial) industrial clusters in the West Kazakhstan region. The general methodology of the present research is based on philosophical and ecological-geographic ideas and concepts, which, in turn, are based on the concept of sustainable development of an area and the principle of polycentric development of production forces in the country. The given paper presents an economic and geographic approach to the formation and development of geographic (territorial) industrial clusters in Kazakhstan regions. Recommendations are developed regarding territorial and structural transformation and modernization of the West Kazakhstan region economy, based on mobilization and an effective use of natural resources, new forms of productive forces territorial organization (geographic (territorial) industrial clusters).