The reproductive system of adolescents is exposed to a high risk of anomalies. In spite of the successes of surgical correction, the percentage of postoperative complications remains high. Special attention should be paid to circumcision, which is regarded as a religious tradition in many countries and carried out with sanitary violations. This research developed a systematic algorithm for the prevention of complications of surgical interventions in case of external genitalia anomalies. The article describes results of a statistical analysis related to the main risk factors of postoperative complications in primary genital surgery in male adolescents. The analysis implied calculating the frequency of value occurrence, the percentage of value occurrence, and cumulative frequency. Using the Spearman criterion, we carried out correlation analysis; 11 predicts of complications in the postoperative period during manipulations on the genitals were determined with regard to logistic regression. Comparison of the interdependent variables by using the Chi-square method and the Wilcoxon test gave the possibility to determine statistically significant differences in the frequency distribution of patients in terms of complications of the main group. A set of necessary measures for preventing postoperative complications was presented in the form of a prevention circle.