The purpose of the article is to present and analyze the results of experimental work to verify the efficiency of the developed and approved program aimed at the formation of social competence in adolescents with physical problems. The leading method in the study of this problem is a consequent version of the pedagogical experiment. The results of this experimental work approved the consistency of the proposed program "I'm in the world of people" to improve the overall indicator level of social competence in adolescents with physical illness and its components, such as cognitive, value-meaningful, activity-based and communicative. The developed program includes content, a variety of forms and methods of pedagogical interaction with teenage pupils with physical problems. The paper identified the differences in systemically important components of social competence of adolescents with poor health at the ascertaining and control stages of the experiment, determined specific nature of socialization and social networking features of the sample participants. The program developed for the formation of social competence in adolescents can be used in the practice of special institutions for children with physical illnesses, as well as recommended for the comprehensive school, contributing to the expansion of the arsenal of tools used for the formation of social competence in adolescents.