Coupled with the most recent national data set, this study investigated the college persistence behavior of first-generation students and found that they were most likely to withdraw from college during their second year. Moreover, this study unpacked the time-varying nature of academic and social integration. The effect of social integration on persistence was strengthened as students progressed in their college careers, whereas the effect of academic integration was greater in the first two years in college. Findings of the current study assist institutions in identifying unique issues triggering withdrawals at specific periods in college, and systematically incorporating these issues in their retention efforts.