Objectives: This study examines the impact of social work interventions in aging on quality of life (QOL) and cost outcomes in four categories (health, mental health, geriatric evaluation and management, and caregiving). Methods: Systematic review methods are employed. Databases were searched for articles published in English between 2004 and 2012 that report outcomes of social work interventions for aging individuals (age = 50) and/or their caregivers/families. Of the 464 identified articles, 45 representing 42 studies met inclusion criteria. Results: Seventy-one percent of the studies report significant QOL outcomes. Twenty-one studies include cost outcomes, with 15 (71.4%) documenting significant cost savings. Twelve (80%) of the studies reporting significant cost outcomes examine social work interventions in health, including care coordination and end-of-life/palliative care. Conclusion: The findings suggest that social work interventions in aging have a positive and significant impact on QOL and cost outcomes. Applications for social work practice and research are discussed.