This article is an exploration of the varying applications of comics and cartoon art as primary resources and pedagogical tools within the university setting. Following some background information on cartoon art forms including early American newspaper comics, nineteenth century humor serials, political cartoons and manga, the article explores how the perception of comics has changed and suggests ways librarians can work with academics to better utilize comics and cartoon art as educational resources. Drawing on the literature and the author's experience of working with Faculty and students at The Ohio State University, this article highlights ways to embed comics and cartoon art into the curriculum in disciplines ranging from Women's Studies to Psychology, ESL, History, Fashion, and more. The article aims to serve as a springboard for "thinking outside of the box" to maximize the value and use of library collections.