This study investigated usability of educational software: case of "?pón-Ìm?`" in Osun state, Nigeria. Specifically, the study investigated influences of gender and school locations on students' assessment of "?pón-Ìm?`" Technology Enhanced Learning System (OTELS) based on selected usability parameters. 701 students were selected from six secondary schools across the three Senatorial districts of the state. A researcher-developed instrument: Educational Software Usability Assessment Questionnaire (ESUAQ) was used for data collection. Using Pearsons Product Moment Correlation statistics, the instrument yielded reliability value of 0.87. t-test and ANOVA were used to test hypotheses one to five and six to ten respectively. Scheffe's post-hoc test was used to locate the direction of difference established in ANOVA. The study revealed that gender and school location had no significant influence on students' satisfaction with OTELS (t (666) = 1.21, p>0.05., F (2, 665) = 0.436, p>0.05); efficiency (t (666) = 0.68, p>.05, F (2, 665) = 2.420, p>0.05); retentiveness (t (666) = 1.22, p>0.05, F (2, 665) = 2.792, p>0.05) and error prevention (t (666) = 0.15, p>0.05,). School location had significant influence on learnability of the software, F (2, 665) = 10.87, p<0.05.The study recommends that Osun state government may take into account students' location when teaching them how to use the software.