Cultural factors significantly influence the effectiveness of pediatric screening that enables the prevention of developmental disturbances. The formulation of intervention programs must match the needs of the child, his or her family, and educators. Recognizing the importance of creating an intervention program accessible to the culture of the child and the child's mentors, this article describes a multidisciplinary early screening and preventive intervention program for preschool boys within the ultra-Orthodox sector. The adaptation strategy for intervention in the ultra-Orthodox community included both surface changes and deep restructuring of content and delivery. Lessons learned were applied to pilot testing resulting in a feasible model.