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ERIC Number: EJ1108721
Record Type: Journal
Publication Date: 2016-Aug
Pages: 5
Abstractor: As Provided
ISSN: ISSN-1072-0502
Stimulant Drug Effects on Touchscreen Automated Paired-Associates Learning (PAL) in Rats
Roschlau, Corinna; Votteler, Angeline; Hauber, Wolfgang
Learning & Memory, v23 n8 p422-426 Aug 2016
Here we tested in rats effects of the procognitive drugs modafinil and methylphenidate on post-acquisition performance in an object-location paired-associates learning (PAL) task. Modafinil (32; 64 mg/kg) was without effect, while higher (9 mg/kg) but not lower (4.5 mg/kg) doses of methylphenidate impaired PAL performance. Likewise, higher but not lower doses of amphetamine (0.4; 0.8 mg/kg) and MK-801 (0.08; 0.12 mg/kg) decreased PAL performance. Impaired PAL performance induced by methylphenidate, amphetamine, and MK801 most likely reflects compromised cognitive function, e.g., retrieval of learned paired associates. Our data suggest that stimulant drugs such as methylphenidate and modafinil might not facilitate performance in hippocampus-related cognitive tasks.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A