ERIC Number: EJ1108711
Record Type: Journal
Publication Date: 2016-Aug
Abstractor: As Provided
Inhibition of Protein Synthesis but Not ß-Adrenergic Receptors Blocks Reconsolidation of a Cocaine-Associated Cue Memory
Dunbar, Amber B.; Taylor, Jane R.
Learning & Memory, v23 n8 p391-398 Aug 2016
Previously consolidated memories have the potential to enter a state of lability upon memory recall, during which time the memory can be altered before undergoing an additional consolidation-like process and being stored again as a long-term memory. Blocking reconsolidation of aberrant memories has been proposed as a potential treatment for psychiatric disorders including addiction. Here we investigated the effect of systemically administering the protein synthesis inhibitor cycloheximide or the ß-adrenergic antagonist propranolol on reconsolidation. Rats were trained to self-administer cocaine, during which each lever press resulted in the presentation of a cue paired with an intravenous infusion of cocaine. After undergoing lever press extinction to reduce operant responding, the cue memory was reactivated and rats were administered systemic injections of propranolol, cycloheximide, or vehicle. Post-reactivation cycloheximide, but not propranolol, resulted in a reactivation-dependent decrease in cue-induced reinstatement, indicative of reconsolidation blockade by protein synthesis inhibition. The present data indicate that systemically targeting protein synthesis as opposed to the ß-adrenergic system may more effectively attenuate the reconsolidation of a drug-related memory and decrease drug-seeking behavior.
Descriptors: Cocaine, Brain, Inhibition, Memory, Recall (Psychology), Cues, Mental Disorders, Drug Addiction, Drug Rehabilitation
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: firstname.lastname@example.org; Web site: http://learnmem.cshlp.org
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A