This study investigated users' satisfaction with library information resources and services at the College of Health Sciences (CHS) library Niger Delta University, Nigeria. The objective was to determine the level of users satisfaction with library information resources and services. 2 (two) research questions were formulated to guide the study. The survey research design was adopted, using a population of 687 registered users in the College of Health Sciences Library. The sample size of 180 was selected through random sampling technique. The instrument used for data collection was a self-designed questionnaire. Among the results of the study showed that users were satisfied with the lending services of library, renewal of library materials and longer hours of internet services in the library. It was also revealed in the study that users were dissatisfied with the limited reference materials in their various subject areas, national and international journals because they were not up to date.