Sixty fourth- and fifth-grade general education teachers were randomly assigned to teach Collaborative Strategic Reading (CSR; Klingner, Vaughn, Boardman, & Swanson, 2012), a set of reading comprehension strategies, or to a business-as-usual comparison group. Results demonstrate that students with learning disabilities (LD) who received CSR instruction in their general education classrooms--approximately 2 times each week over a 14-week period--made significantly greater gains in reading comprehension than students with LD in comparison classrooms (g = 0.52). Teachers in CSR classrooms were also more likely to provide feedback to students and to use collaborative grouping structures.