With electronic technologies, differentiated instruction has the same meaning as in traditional instruction, but different tools are available for teachers to help students learn. Electronic technologies for differentiated instruction can add powerful new types of media inclusion, levels of interactivity, and response actions. This rapidly emerging approach to differentiated instruction also can enhance ability to collect data on the fly and to deliver custom content. This paper considers some self-selection strategies for differentiated instruction online, and presents the results of one study to explore student use of self-selection.