This research aims to develop valid and practical teaching materials for mathematics and science lesson PISA-based for junior high school students and to determine potential effects on students in scientific activity. Subjects of this study were students of Junior High School 9 Palembang (SMP Negeri 9 Palembang). The method used in this study is the Development Research consists of three stages: preliminary, prototyping, and assessment. Data collection techniques used in this study is walk through (expert review stage) to determine the validity of teaching materials in terms of content, construct, and language; interview (one-to-one and small group stage) to determine the practicality of teaching materials, and field tests stage to determine the potential effects of instructional materials. From the analysis of the research data, it can be concluded that: this study produced two instructional materials namely mathematics instructional materials with topic similarity and science instructional materials with topic temperature and its amendment. The teaching materials have the potential effects on the students in scientific activities.