Our paper describes a solution we found to a still existing need to develop mathematical modeling courses for undergraduate biology majors. Some challenges of such courses are: (i) relatively limited exposure of biology students to higher-level mathematical and computational concepts; (ii) availability of texts that can give a flavor of how contemporary biological problems are approached with quantitative methods; (iii) expectations to cover specific mathematical (or biological) content rather than teach a problem-solving approach. We solved these challenges by designing a course where several modules were developed, each beginning with a presentation from a campus expert in a biological area of research and concluding with a seminar-style student-led paper presentation of an article that addresses the biological problem using mathematical and computational tools. The aim of the course was to expose students to the vast possibilities and potential in quantitative biology, and to give them a vocabulary to collaborate with mathematicians, statisticians, and computer scientists.