The purpose of this study was to address the importance of spiritual well-being and hope among cancer patients diagnosed with its different stages. Through stratified sampling techniques, 120 cancer patients from four stages evenly divided into male and female participated in this study. Spiritual Well-being Scale (Paloutzian & Ellison, 1982) and Hope Scale (Snyder, Harris, Anderson, et al, 1991) were used to measure the levels of spiritual well-being and hope respectively. Results indicated a significant positive relationship between spiritual well-being and hope among cancer patients of all stages while surprisingly this relationship was higher in last stage of cancer patients. The findings showed that patients in last stage of cancer have high hope and high spiritual well-being than that of other stages. The findings pertaining to gender differences showed that female cancer patients have high level of hope and spiritual well-being as compared to male cancer patients.