ERIC Number: EJ1101552
Record Type: Journal
Publication Date: 2016-May
Pages: 4
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: N/A
A Hydrazine-Free Wolff-Kishner Reaction Suitable for an Undergraduate Laboratory
Cranwell, Philippa B.; Russell, Andrew T.
Journal of Chemical Education, v93 n5 p949-952 May 2016
A Wolff-Kishner reaction that does not require hydrazine has been developed. The reaction sequence has two steps: formation of a carbomethoxyhydrazone from methyl hydrazinocarboxylate and acetophenone, then decomposition of this intermediate by treatment with potassium hydroxide in triethylene glycol. Purification is by filtration through a plug of silica encased in the barrel of a plastic syringe. The reaction sequence can be completed within a day-long laboratory class (8 h).
Descriptors: Undergraduate Study, Chemistry, Organic Chemistry, Laboratory Experiments, Hands on Science, Experiential Learning, Science Instruction, Undergraduate Students, Laboratory Safety, Hazardous Materials
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A