NotesFAQContact Us
Search Tips
Peer reviewed Peer reviewed
Direct linkDirect link
ERIC Number: EJ1101502
Record Type: Journal
Publication Date: 2016-May
Pages: 5
Abstractor: As Provided
ISSN: ISSN-0021-9584
Combinatorial Solid-Phase Synthesis of Aromatic Oligoamides: A Research-Based Laboratory Module for Undergraduate Organic Chemistry
Fuller, Amelia A.
Journal of Chemical Education, v93 n5 p953-957 May 2016
A five-week, research-based experiment suitable for second-semester introductory organic laboratory students is described. Each student designs, prepares, and analyzes a combinatorial array of six aromatic oligoamides. Molecules are prepared on solid phase via a six-step synthetic sequence, and purities and identities are determined by analysis of LC-MS data. This experiment engages students in a research experience: none of the structurally diverse compounds prepared have been previously reported in the literature. After completion of this experiment, products are evaluated for their biological activity in the author's research laboratory. Although execution of biological experiments falls outside the learning objectives in this course, these applications motivate students. Through these hands-on experiences, students learn about organic chemistry reactions and modern techniques, and their research skills are enhanced.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: National Science Foundation (NSF)
Authoring Institution: N/A
Grant or Contract Numbers: CHE1056520