ERIC Number: EJ1100115
Record Type: Journal
Publication Date: 2016-Jun
Abstractor: As Provided
Reference Count: 64
Widespread White Matter Differences in Children and Adolescents with Autism Spectrum Disorder
Vogan, V. M.; Morgan, B. R.; Leung, R. C.; Anagnostou, E.; Doyle-Thomas, K.; Taylor, M. J.
Journal of Autism and Developmental Disorders, v46 n6 p2138-2147 Jun 2016
Diffusion tensor imaging studies show white matter (WM) abnormalities in children with autism spectrum disorder (ASD). However, investigations are often limited by small samples, particularly problematic given the heterogeneity of ASD. We explored WM using DTI in a large sample of 130 children and adolescents (7-15 years) with and without ASD, whether age-related changes differed between ASD and control groups, and the relation between DTI measures and ASD symptomatology. Reduced fractional anisotropy and axial diffusivity were observed in ASD in numerous WM tracts, including the corpus callosum and thalamocortical fibres--tracts crucial for interhemispheric connectivity and higher order information processing. Widespread WM compromise in ASD is consistent with the view that ASD is a disorder of generalized complex information processing.
Descriptors: Autism, Pervasive Developmental Disorders, Brain, Children, Adolescents, Diagnostic Tests, Brain Hemisphere Functions, Cognitive Processes, Information Processing
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
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