The Every Child Achieves Act of 2015 has drawn greater attention to the academic achievement of students considered at risk who attend alternative schools. Due to problems both inside and outside of schools, students in alternative education settings may struggle with academic content and require a different educational approach. This comprehensive literature review critically examined experimental intervention studies that were conducted in alternative schools published between 1990 and 2013. Eighteen studies met the inclusion criteria. Academic intervention studies conducted in alternative educational settings, limitations, practical implications, and future directions are discussed.