The rationale for students preparation in job creation through entrepreneurship education was examined. Problems of unemployment among Nigerian university graduates and challenges to entrepreneurship in the face of global economic crisis were also highlighted. The persistent problem of unemployment among University graduates and its attendant social problems suggest that urgent emphasis be placed on well structured entrepreneurship education since the National Directorate for employment (NDE) and other government intervention agencies alone cannot cope with entrepreneurship training and employment of youths and unemployed university graduates. The curricular for senior secondary and tertiary education should be reviewed to incorporate entrepreneurship education.