In order to become a UK Nurse Prescriber, a First Level Registered Nurse must undergo an approved University based educational programme, which consists of theory, and a period of practice supervised by doctors. The Nursing and Midwifery Council (NMC) requires nurses undertaking this programme to have some formal university attendance and to be assessed in practice. Successful students are recorded on the national NMC register. Since October 2004, the University of Winchester has used blended learning incorporating e-learning for the delivery of the Nurse Prescribing Programme using online material developed by Emap Publishing in conjunction with the University of Stirling. This paper discusses the effectiveness of the programme and the evaluation of the initial six cohorts ("127 students") who studied the Nurse Prescribing Programme undertaken by e-learning through the University of Winchester.