The increasingly use of technology in education does set off a flurry of research studies that focus on the successfulness and effectiveness of technology in elementary and secondary education. In this study, we conducted a comprehensive meta-analysis of research literature on technology in relation to mathematics teaching and learning. Particularly, the following main research questions were addressed in our meta-analysis: 1. What is the magnitude of the effects of technology on schooling outcomes concerning mathematics education? 2. How does the magnitude of the effects of technology fluctuate in response to various study features (e.g., gender, age, race) and design features (e.g., randomization, sample size, instruments)? Based on a total of 81 independent findings extracted from 39 studies involving a total of 59,147 learners, the results of the series of meta-analyses conducted in this review indicate that technology can affect mathematics teaching and learning.