The full promise of class room learning is dependent on its ability to incorporate 21st century skills in its instructional design, delivery and implementation. In this increasingly competitive global economy, it is not enough for students to acquire subject-level mastery alone. Skills like creative thinking, problem-solving, communication and analytical thinking are necessary for all levels of success. To cope with the demands of the 21st century, students need to know how to use their knowledge and skills-by thinking critically, applying knowledge to new situations, analyzing information, comprehending new ideas, communicating, collaborating, solving problems, and making decisions. If our students are going to compete successfully in the global economy, more must be done to support their acquisition of 21st century skills. This article attempts to articulate a vision for 21st century learning in schools, and identify a way in which a teaching strategy can improve outcomes for all students. The author here tries to infuse the 5E model and technology for the development of 21st century skills in science education curriculum programs and instructional practices.