This study explored the association between social media use, loneliness, and academic achievement in high school students and identified the demographic characteristics associated with these three elements. This study also aimed to identify the percentage of variance in loneliness accounted for by social media use and GPA. Participants were 345 urban high school students from Michigan. A series of t-tests, ANOVAs, and correlational analyses were performed. Gender differences were found for loneliness and the frequency of social media use. Race and grade level differences were found for GPA. Data yielded a weak negative correlation between loneliness and GPA. GPA accounts for about 2% of the variance in loneliness. Practical implications and recommendations for future research are discussed.