This study aims to design a non-simultaneous distance instruction system with affective computing, which integrates interactive agent technology with the curricular instruction of affective design. The research subjects were 78 students, and prototype assessment and final assessment were adopted to assess the interface and usability of the system. Prototype assessment consisted of heuristic assessment and the system usability scale, while final assessment adopted the triangular cross-validation method: where the questionnaire for user interaction satisfaction, observation, and interviews were used to explore the effect of learning and obtain qualitative and quantitative information for analysis. According to the experimental results, the usability of the non-simultaneous distance instruction system with affective computing was high; the respondents showed high-level satisfaction regarding interaction with the affective learning system; the training game response mechanism of the system could effectively improve the emotion of learning; there was a significant improvement in the effect of learning based on the affective learning system.