The purpose of this study is to investigate the differences between genders on the scores of a series of spreadsheet projects in a survey computer information systems course. This study hypothesizes that there will be significance in scores in the ten assigned projects between female students and males students; with the female students scoring higher than male students in a majority of the projects. Additionally, this study hypothesizes that there will be a significant difference in the mean project score for all ten projects with the female students scoring higher than the male students. Group statistics and t-tests were used to determine significance between females and males. Among the discoveries, except for a slight difference in two of the projects, there was no significance between female and male students' project scores. An interesting downward trend in mean scores emerged as the projects progressed.