The authors examine South Dakota's 2+2+2 Project, a collaborative effort between South Dakota State University (SDSU) and the state's tribal colleges designed to enhance educational opportunities for American Indians, through the W. K. Kellogg Foundation's indicators of an engaged institution. Indicators include responsiveness, respect for partners, academic neutrality, accessibility, integration, coordination, and resource partnerships. Through this project SDSU aims to address expressed needs by attracting and retaining American Indian high school students and offering them opportunities to become familiar with careers in food science, early childhood education, natural resources, and agriculture. Program components, evaluation, mutual benefits, challenges, and broader implications are discussed.