The paper examined the effects of a Technological Instructional Package (TIP) on secondary school students' performance in biology. The study adopted a pre-test, post-test experimental control group design. The sample size of the study was 80 students from Minna metropolis, Niger state, Nigeria; the samples were randomly assigned into treatment group 40 (male = 18 and female = 22) and control 40 (male = 20, female = 20). The researcher developed package was validated by experts. The data collection instrument was a Biology Achievement Test which yielded a reliability coefficient of 0.74. The treatment group was taught with TIP while the control group was taught with traditional teaching methods. The data obtained were analyzed using split-plot Analysis of Variance (SPANOVA) and t-test. The results of data analysis revealed there was an interaction effect, treatment was effective in significantly improving students' performance in the experimental group than the control group (F (1.78) =29. 89, p < 0.05) in the main effects. The TIP was found to be gender friendly (t = 3.93, df = 38, p > 0.05). Based on the finding, it was recommended that teachers should be trained and encouraged to employ technological resources in their classroom practices.