For many decades, the attitude of nurses has been an area of interest for researchers. The major reason for this interest is the profound impact of nurse's attitude like organizational cynicism on many organizational outcomes. The present study is aimed to describe organizational cynicism, level of perceived organizational support, and the sequences of organizational cynicism on nurses and quality of care. Correlation descriptive cross-sectional study was carried out amongst 368 nurses working in critical care and toxicology units. The independent variable was organizational cynicism, while the dependent variables were nurse work outcomes and quality of care. The study shows high level of organizational cynicism among nurses in critical care units and low level of perceived organizational support. It also shows a negative relation between organizational cynicism and perceived organizational support, organizational commitment, job satisfaction, and quality of care. As their cynicism level increased, their perceived level of organizational support, nurses' commitment, job satisfaction, and quality of care decreased. In addition, it was obvious that nurses' perception for organizational cynicism has a positive and significant effect on deviant workplace behavior, and their leaving of employing organization and burnout.