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ERIC Number: EJ1093170
Record Type: Journal
Publication Date: 2016-Apr
Pages: 10
Abstractor: As Provided
ISSN: ISSN-0162-3257
Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review
Jain, Seema; Andridge, Rebecca; Hellings, Jessica A.
Journal of Autism and Developmental Disorders, v46 n4 p1344-1353 Apr 2016
Loxapine substitution is a promising option for patients with autism spectrum disorder (ASD) who develop antipsychotic-induced metabolic illness. We performed a chart review of 15 adolescents and adults meeting DSM-IV-TR criteria for ASD, all with antipsychotic-associated weight gain, who received low dose loxapine in an attempt to taper or discontinue the weight gain-associated antipsychotic. Mean weight loss was -5.7 kg, mean BMI reduction was -1.9, and mean triglyceride reduction was -33.7 mg/dl. At chart review, 14 of 15 subjects were rated 2 (Much Improved) or 1 (Very Much Improved) on the Clinical Global Impressions-Improvement scale (CGI-I). Low dose loxapine addition in most cases enabled taper of offending antipsychotics, significantly reversed drug-induced metabolic disturbances and improved irritability.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A