This research aims to produce a learning instrument based on hypermedia which is valid, interesting, practical, and effective as well as to know its influence on the problem based skill of students Mathematical and Science Faculty, Makassar State University. This research is a research and development at (R&D) type. The development procedure was referred to Four-D model consisted of definition phase, design phase, development phase and dissemination phase. The trial test used non-equivalent control group design. The subject of this study was 14 students year 2014/2015 majoring Physics Education as a control class and 30 students of International Class Program (ICP) of Physics Education as an experimental class. The data analysis used Content Validity Ratio (CVR), descriptive analysis, and inferential analysis. The results obtained after applying physics learning instrument based on hypermedia were valid, interesting, practical, and effective assessment. Based on descriptive analysis the average score of ICP class (experimental class) was higher than those of physics education (control class) and the test result based on t-test it was found that there is significantly difference of problem solving skill between control class which used power point with experimental class which used learning instrument based on hypermedia. The results showed that its differences identify the increase of problem solving skill which consists of mapping problems, mathematical skills, numerical skill, space and graph awareness, and estimation skill. Thus, physics learning instrument based on hypermedia can give influence the improvement of problem solving skill of students in FMIPA UNM.