The Tanzania's higher education institutions haven't raised much of expectations the graduates lack the skills required by the labor market and this trend results in mass graduate unemployment, otherwise this would have assisted them to be more self-reliant. The study explores the importance of higher-level business education human resources development for youth empowerment and national development in Tanzania. The non-stop-increasing pace of technological changes in the fields of business and economy mostly has rendered the teaching of business skills and the training of skilled manpower ever more challenging. The ever-increasing pace of technological changes in the fields of business and economy generally has rendered the teaching of business skills and the training of skilled manpower ever more challenging. The problem caused by this development, is the search for graduates and competent business educators with the knowledge and skills needed by employers of labor in business offices, industry and public sector. This paper will explore why large numbers of University graduates go jobless for months or even years, while labor complain of lack of skilled workers; and how can the Universities assist in training skilled business graduates for the Tanzania economy? The task of creating skilled human resources development for youth empowerment, productivity, and efficiency in society lies with skillful and experienced trainers and the quality of the training institutions. The implications of the development of a virile higher-level skilled work force for the economy is critically analyzed and recommendations are made to relevant publics, especially the universities and its tutors.