Poor performance of students in agricultural science at the internal and external examinations has been attributed to ineffectiveness of the agricultural science teachers at the secondary schools in Afikpo education zone of Ebonyi State, therefore, this research determined the mechanisms for enhancing the teachers' effectiveness in the implementation of secondary school agricultural science programme. The study adopted survey research design. The population of the study was 117 and there was no sampling, rather the whole population was studied. A structured questionnaire was used to collect data for the study. The instrument had 4 points modified Likert scale. The instrument was validated by using Cronbach alpha which yielded reliability co-efficient of 0.96. Data were collected by the researcher administering the questionnaire to the respondents. Data analyzes involved both descriptive and inferential statistics. Based on the analysis of the data, it was revealed among others that provision of incentives, regular training and retraining of the teachers enhance the effectiveness of the teachers in the implementation of the secondary school agricultural science programme. Based on the findings, it was recommended, among others, that the Ebonyi State Ministry of education in collaboration with the school principals should try to provide incentives to the teachers and organize conferences, seminars and workshops to update the teachers' knowledge.