This study examined age-related associations between goal disengagement capacities, emotional distress, and disease severity across older adulthood. Given that an age-related increase in the experience of stressors might render important goals unattainable, it is expected that goal disengagement capacities would predict a decrease in the severity of experienced illness (i.e., the common cold) by preventing emotional distress (i.e., depressive symptoms), particularly so among individuals in advanced (as compared to early) old age. This hypothesis was tested in a 6-year longitudinal study of 131 older adults (age range = 64 to 90). Regression analyses showed that goal disengagement capacities buffered 6-year increases in older adults' cold symptoms, and that this effect was significantly pronounced among older-old participants. Mediation analyses further indicated that changes in depressive symptoms exerted an indirect effect on the age-related association between goal disengagement and changes in cold symptoms. The study's findings suggest that goal disengagement capacities become increasingly important for protecting emotional well-being and physical health as older adults advance in age.