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ERIC Number: EJ1090634
Record Type: Journal
Publication Date: 2016-Feb
Pages: 4
Abstractor: As Provided
Reference Count: 17
ISSN: ISSN-0021-9584
Self-Assembly, Guest Capture, and NMR Spectroscopy of a Metal-Organic Cage in Water
Go, Eun Bin; Srisuknimit, Veerasak; Cheng, Stephanie L.; Vosburg, David A.
Journal of Chemical Education, v93 n2 p368-371 Feb 2016
A green organic-inorganic laboratory experiment has been developed in which students prepare a self-assembling iron cage in D[subscript 2]O at room temperature. The tetrahedral cage captures a small, neutral molecule such as cyclohexane or tetrahydrofuran. [Superscript 1]H NMR analysis distinguishes captured and free guests through diagnostic chemical shifts, splitting patterns, diffusion coefficients (using DOSY), and the appearance of captured hydrophobic molecules in D[subscript 2]O even when free guests are insoluble in water. Students are invited to test their hypotheses about guest binding and to perform control and competition experiments. All of the reagents are commercial, the 23-component self-assembly is complete in 1 week at room temperature (requiring neither workup nor purification), and the product solution is intensely purple. In their laboratory reports, students effectively related organic chemistry with molecular self-assembly, supramolecular chemistry, and host-guest interactions.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: National Science Foundation (NSF)
Authoring Institution: N/A
Identifiers - Location: California
IES Grant or Contract Numbers: CHE1005253